Effects of short-term addition of NSAID to diuretics and/or RAAS-inhibitors on blood pressure and renal function.

Background: The combined post-operative use of diuretics and/or renin-angiotensin-aldosterone system (RAAS) inhibitors may increase the risk of nonsteroidal anti-inflammatory drug (NSAID) associated renal failure because of a drug-drug interaction.

Objective: The aim of this study was to investigate the effect of the short-term (<4 days) post-operative combined use of NSAIDs with diuretics and/or RAAS inhibitors on renal function and blood pressure.

Setting: One teaching hospital in the Netherlands.