Publications by authors named "Alex F Goodall"
Article Synopsis
- This pilot study investigated whether patients with Systemic Sclerosis (SSc) have diffuse fibrosis in their peripheral muscles, using MRI to measure extracellular volume (ECV).
- Twelve SSc patients (some with suspected myopathy) and ten healthy controls were examined, with results showing that SSc patients had significantly higher skeletal muscle ECV compared to healthy individuals.
- The findings suggest a link between higher ECV and suspected myopathy in SSc patients, indicating that fibrotic changes in their muscles may be present; however, more research is needed for further understanding.
Objectives: Fetal "black bone" MRI could be useful in the diagnosis of various skeletal conditions during pregnancy without exposure to ionizing radiation. Previously suggested susceptibility-weighted imaging (SWI) is not available in the suggested form on all scanners leading to long imaging times that are susceptible to motion artefacts. We aimed to assess if an optimized T2*-weighted GRE sequence can provide viable "black bone" contrast and compared it to other sequences in the literature.
View Article and Find Full Text PDFObjective: This study aimed to assess the feasibility of extracellular volume-fraction (ECV) measurement, and time to achieve contrast equilibrium (CE), in healthy muscles, and to determine whether in-flow and partial-volume errors in the femoral artery affect measurements, and if there are differences in the partition coefficient (λ) between muscles.
Methods: T1 was measured in the biceps femoris, vastus intermedius, femoral artery and aorta of 10 healthy participants. This was repeated alternately between the thigh and aorta for ≥25 min following a bolus of gadoterate meglumine.