Publications by authors named "Alex DesJarlais"
Article Synopsis
- Gliomatosis cerebri (GC) is a rare and aggressive brain tumor that affects multiple lobes and is associated with a poorer prognosis compared to other gliomas, despite being classified differently under new WHO guidelines.
- The case study describes a 64-year-old male with GBM and extensive GC who responded well to treatment with tumor-treating fields (TTFields) combined with radiation and chemotherapy, showing significant improvement in his condition shortly after treatment.
- Though his glioma recurred 11 months after surgery, the aggressive GC remained under control, leading to a progression-free survival of 11 months and an overall survival of 17 months before his passing.
H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.
J Cachexia Sarcopenia Muscle
December 2021
Background: Skeletal muscle atrophy is a debilitating complication of many chronic diseases, disuse conditions, and ageing. Genome-wide gene expression analyses have identified that elevated levels of microRNAs encoded by the H19X locus are among the most significant changes in skeletal muscles in a wide scope of human cachectic conditions. We have previously reported that the H19X locus is important for the establishment of striated muscle fate during embryogenesis.
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