Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution.

The 3D architecture of RNAs governs their molecular interactions, chemical reactions, and biological functions. However, a large number of RNAs and their protein complexes remain poorly understood due to the limitations of conventional structural biology techniques in deciphering their complex structures and dynamic interactions. To address this limitation, we have benchmarked an integrated approach that combines cryogenic OrbiSIMS, a state-of-the-art solid-state mass spectrometry technique, with computational methods for modelling RNA structures at atomic resolution with enhanced precision.

Retroperitoneal liposarcoma weighing over one hundred pounds with review of the literature.

Background: Rarely, excessively large, slow growing tumors are found to be malignant. One exception includes retroperitoneal tumors, which if considered a mass of pelvic origin, may be encountered by the gynecologic oncologist.

Case: A post-menopausal female was referred for evaluation of a huge mass thought to arise from the pelvis.

Recurrent colorectal carcinoma detected by routine cervicovaginal papanicolaou smear testing.

Background: We present a case of recurrent colon cancer detected by routine, annual Papanicolaou screening.

Case: A 59-year-old African American woman who had been treated for T2N0M0 (stage II, Dukes A) colon cancer 2 years before to presentation had a Pap smear showing a high-grade squamous intraepithelial lesion with a normal cervical biopsy result. Because of this discrepancy, a loop electrosurgical excision procedure and endocervical curettage were performed and showed atypical glandular cells suspicious for adenocarcinoma.

Triplet heterotopic pregnancy after gonadotropin stimulation and intrauterine insemination diagnosed at laparoscopy: a case report.

Heterotopic pregnancy has been traditionally considered a rare event; however, with the use of assisted reproductive technology, the incidence of heterotopic pregnancies is increasing. Diagnosing a heterotopic pregnancy can be challenging. This report describes a 30-year-old female at 11 weeks' gestation with an intrauterine twin pregnancy after gonadotropin stimulation and intrauterine insemination who presented complaining of left lower quadrant abdominal pain with constipation and cramps.

Female patients' sex preferences in selection of gynecologists and surgeons.

Objectives: In this study, the authors investigated sex preferences for gynecologists and surgeons among female patients, and explored potential contributing factors.

Methods: One hundred forty-six female patients were surveyed in a private practice office concerning their sex preferences and past obstetric/gynecologic care. For data comparisons, chi2 or Fisher exact tests were used.

Metastatic uterine serous carcinoma originating in an endometrial polyp: a report of 2 cases.

Background: Endometrial carcinoma is the most common cancer of the female genital tract. Two histologic variants have been described: an estrogen-dependent form and a more aggressive, non-estrogen-dependent form, which includes uterine serous carcinoma.

Cases: Two cases of uterine serous carcinoma were confined to an endometrial polyp without myometrial invasion and were widely metastatic.

Uterine incarceration in a 9-week multifetal pregnancy resulting from in vitro fertilization. A case report.

Background: Although retroversion of the uterus is a common finding, incarceration of the gravid uterus is a rare complication. It occurs usually between the 12th and 16th weeks of gestation and can lead to severe complications. No case of incarceration has been reported before in a multifetal gestation resulting from in vitro fertilization.