Risk of colectomy in patients with ulcerative colitis under thiopurine treatment.

Background And Aims: Little is known about the risk factors of colectomy in patients with ulcerative colitis (UC) under thiopurine treatment. The aim of the study was to determine the prevalence and the predictive risk factors of colectomy in an extensive cohort of patients with UC treated with thiopurines in Spain.

Methods: Among 5753 UC patients, we identified those diagnosed between 1980 and 2009 and treated with azathioprine or mercaptopurine (AZA/MP).

Outcome in obscure gastrointestinal bleeding after capsule endoscopy.

Aim: To investigate the clinical impact of capsule endoscopy (CE) after an obscure gastrointestinal bleeding (OGIB) episode, focusing on diagnostic work-up, follow-up and predictive factors of rebleeding.

Methods: Patients who were referred to Hospital del Mar (Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid anti-inflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings (significant or non-significant), work-up and patient outcomes were analyzed from electronic charts.

Observational study on the efficacy of adalimumab for the treatment of ulcerative colitis and predictors of outcome.

Background: Information on efficacy and predictors of response to adalimumab in ulcerative colitis (UC) clinical practice is limited.

Aim: Assessment of response to adalimumab and its predictors in an observational cohort study.

Methods: Retrospective cohort study based on data obtained from ENEIDA registry.