The Addition of Navigation Technology to the Femur-First Approach in Anterior Total Hip Arthroplasty Improves Leg Length Restoration.

Background: The addition of computer navigation (CN) technology in direct anterior approach (DAA) total hip arthroplasty (THA) has the potential to improve restoration of hip offset and leg length. In this investigation, we examine the effect of one fluoroscopic-based CN system on biomechanical parameters in DAA THA with femur-first (FF) workflow.

Methods: A retrospective review was performed on 235 primary DAA FF THA cases, with 100 CN cases and 135 in the conventional fluoroscopic overlay (FO) group.

Coassembly of amphiphiles with opposite peptide polarities into nanofibers.

The design, synthesis, and characterization of "reverse" peptide amphiphiles (PAs) with free N-termini is described. Use of an unnatural amino acid modified with a fatty acid tail allows for the synthesis of this new class of PA molecules. The mixing of these molecules with complementary ones containing a free C-terminus results in coassembled structures, as demonstrated by circular dichroism and NOE/NMR spectroscopy.