Publications by authors named "Alex Burr"
Gene expression is controlled by dynamic localization of thousands of regulatory proteins to precise genomic regions. Understanding this cell type-specific process has been a longstanding goal yet remains challenging because DNA-protein mapping methods generally study one protein at a time. Here, to address this, we developed chromatin immunoprecipitation done in parallel (ChIP-DIP) to generate genome-wide maps of hundreds of diverse regulatory proteins in a single experiment.
View Article and Find Full Text PDFThe nucleus is highly organized, such that factors involved in the transcription and processing of distinct classes of RNA are confined within specific nuclear bodies. One example is the nuclear speckle, which is defined by high concentrations of protein and noncoding RNA regulators of pre-mRNA splicing. What functional role, if any, speckles might play in the process of mRNA splicing is unclear.
View Article and Find Full Text PDFArticle Synopsis
- - Benign prostate hyperplasia and prostate cancer both involve excessive growth of prostate tissue, highlighting the need to understand the normal progenitor cells in the prostate and identify potential drug targets.
- - Researchers used single-cell RNA sequencing (scRNA-Seq) to identify a specific population of luminal progenitor cells in the prostate of mice, both with and without hormonal treatment.
- - The study found key factors essential for regenerating prostate organoids from mice and humans, suggesting scRNA-Seq can help uncover potential pharmacologic strategies aimed at the cell populations responsible for prostate diseases.