Analysis of associations between the SNPs rs3775291 and rs3775290 and COVID-19 in a cohort of professionals of Belém-PA, Brazil.

The objective of this article was to verify associations between the SNPs rs3775291 (Cytosine [C]>Thymine [T]) and rs3775290 (C>T) of in professionals from Health Institutions (HI) who worked during the first pandemic wave and COVID-19. A case-control study was carried out with workers from HI in Belém-PA, Brazil, divided into symptomatology groups (Asymptomatic-AS, =91; and Symptomatic-SI, =121), and severity groups, classified by Chest CT scan (symptomatic with lung involvement - SCP, =34; symptomatic without lung involvement - SSP, =8). Genotyping was performed by Sanger sequencing and statistical analysis was performed using the SPSS program.

Endemic High-Risk Clone ST277 Is Related to the Spread of SPM-1-Producing during the COVID-19 Pandemic Period in Northern Brazil.

is a high-priority bacterial agent that causes healthcare-acquired infections (HAIs), which often leads to serious infections and poor prognosis in vulnerable patients. Its increasing resistance to antimicrobials, associated with SPM production, is a case of public health concern. Therefore, this study aims to determine the antimicrobial resistance, virulence, and genotyping features of strains producing SPM-1 in the Northern region of Brazil.