Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure.

Acute primary open angle glaucoma is an optic neuropathy characterized by the elevation of intraocular pressure, which causes retinal ischemia and neuronal death. Rat ischemia/reperfusion enhances endocytosis of both horseradish peroxidase (HRP) or fluorescent dextran into ganglion cell layer (GCL) neurons 24 h after the insult. We investigated the activation of autophagy in GCL-neurons following ischemia/reperfusion, using acid phosphatase (AP) histochemistry and immunofluorescence against LC3 and LAMP1.

Micropulse diode laser trabeculoplasty (MDLT): A phase II clinical study with 12 months follow-up.

Objective: This pilot study evaluates the pressure lowering potential of subthreshold micropulse diode laser trabeculoplasty (MDLT) for a clinically meaningful duration in patients with medically uncontrolled open angle glaucoma (OAG).

Design: prospective interventional case series.

Participants: Thirty-two eyes of 20 consecutive patients with uncontrolled OAG (12 bilateral and 8 unilateral).

Eye injuries in an Italian urban population: report of 10,620 cases admitted to an eye emergency department in Torino.

Background: Ocular trauma has significant impact on the patient's future quality of life. Most of the hospital-based studies tend to underestimate the occurrence of minor ocular trauma. In Torino the large majority of patients with ocular trauma are referred to a single hospital with a 24-hour Emergency Department (Ospedale Oftalmico).