Publications by authors named "Alex Barksdale"
Magnetic particle imaging (MPI) was introduced in 2005 as a promising, tracer-based medical imaging modality with the potential for high sensitivity and spatial resolution. Since then, numerous preclinical devices have been built but only a few human-scale devices, none of which targeted functional neuroimaging. In this work, we probe the challenges of scaling the technology to meet the needs of human functional neuroimaging with sufficient sensitivity for detecting the hemodynamic changes following brain activation with a spatio-temporal resolution comparable to current functional magnetic resonance imaging approaches.
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- Magnetic fields that switch at high frequencies (kHz) can cause peripheral nerve stimulation (PNS) in the body, and this has primarily been studied below 10 kHz.
- Previous studies above ~25 kHz showed inconsistent results with high variability, but new research involving 8 volunteers measured PNS at frequencies from 200 Hz to 88.1 kHz.
- Results indicated that instead of continuously decreasing, the PNS thresholds hit a minimum around 25 kHz and then increased by 39% from that point to 88.1 kHz, highlighting the need for more research on the biological mechanisms behind magnetostimulation at these higher frequencies.