Publications by authors named "Alex Acosta"

Visual detection of stromata (brown-black, elevated fungal fruiting bodies) is the primary method for quantifying tar spot early in the season because these structures are definitive signs of the disease and essential for effective disease monitoring and management. Here, we present the Stromata Contour Detection Algorithm version 2 (SCDA v2), which addresses the limitations of the previously developed SCDA version 1 (SCDA v1), without the need to empirically search for optimal decision-making input parameters (DMIPs) while achieving higher and consistent accuracy in tar spot stromata detection. SCDA v2 operates in two components: (i) SCDA v1 producing tar spot-like region proposals for a given input corn leaf Red-Green-Blue (RGB) image and (ii) a pretrained convolutional neural network (CNN) classifier identifying true tar spot stromata from the region proposals.

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Article Synopsis
  • The OpACIN-neo trial aimed to find a less toxic yet equally effective dosing schedule for the combination treatment of ipilimumab and nivolumab in patients with macroscopic stage III melanoma, as current doses had high toxicity and limited broader use.
  • The trial involved 18+ year-old patients with resectable stage III melanoma and included three different neoadjuvant dosing regimens across multiple medical centers in Australia, Sweden, and the Netherlands.
  • Primary endpoints of the study focused on measuring severe immune-related toxicities within the first 12 weeks and the rates of radiological and pathological responses six weeks after treatment.
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An eleven year old boy presented with headaches and dizziness associated to micturition. On radiologic imaging, he was found with a bladder mass. The biochemical work up was suggestive of pheochromocytoma.

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