Synthesis, Complexation Properties, and Evaluation of New Aminodiphosphonic Acids as Vector Molecules for Ga Radiopharmaceuticals.

Two new aminodiphosphonic acids derived from salicylic acid and its phosphonic analogue were prepared through a simple and efficient synthesis. 2-[(2-Amino-2,2-diphosphono)ethyloxy]-benzoic acid and 2-[(2-amino-2,2-diphosphono)ethyloxy]-5-ethyl-phenylphosphonic acid were evaluated for their applicability as Ga binding bone-seeking agents. Protonation constants of and and stability constants of the Ga complexes with and in water were determined.

Pharmacokinetic Properties of Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag.

The folate receptor (FR) is a promising cell membrane-associated target for molecular imaging and radionuclide therapy of cancer (FR-α) and potentially also inflammatory diseases (FR-β) through use of folic acid-based radioconjugate. FR is often overexpressed by cells of epithelial tumors, including tumors of ovary, cervix, endometrium, lungs, kidneys, etc. In healthy tissues, FR can be found in small numbers by the epithelial cells, mainly in the kidneys.

Speciation of heptavalent technetium in sulfuric acid: structural and spectroscopic studies.

The speciation of Tc(vii) was studied in 12 M H(2)SO(4) by NMR, UV-visible and XAFS spectroscopy. Experimental results and density functional calculations show the formation of TcO(3)(OH)(H(2)O)(2).