Influence of Sleep Time on the Consumption of Ultra-Processed Foods in Adolescents in a Capital of Brazil: A Longitudinal Study.

Background/objectives: The study prospectively assessed the association between sleep duration and the consumption of ultra-processed foods in adolescent students from a Brazilian capital.

Methods: We observed 1431 adolescents participating in the Longitudinal Study on sedentary behavior, physical activity, dietary habits, and adolescent health, aged 10 to 14 years, in the years 2014 to 2017. The percentage of consumption of ultra-processed foods was evaluated by the Friedman test.

The direct correlation between oxidative stress and LDL-C levels in adults is maintained by the Friedewald and Martin equations, but the methylation levels in the MTHFR and ADRB3 genes differ.

Low-density lipoprotein (LDL-C) concentrations are a standard of care in the prevention of cardiovascular disease and are influenced by different factors. This study compared the LDL-C concentrations estimated by two different equations and determined their associations with inflammatory status, oxidative stress, anthropometric variables, food intake and DNA methylation levels in the LPL, ADRB3 and MTHFR genes. A cross-sectional population-based study was conducted with 236 adults (median age 37.

Methylation profile of the ADRB3 gene and its association with lipid profile and nutritional status in adults.

Background: Defects in DNA methylation have been shown to be associated with metabolic diseases such as obesity, dyslipidemia, and hypercholesterolemia. To analyze the methylation profile of the ADRB3 gene and correlate it with lipid profile, lipid intake, and oxidative stress based on malondialdehyde (MDA) and total antioxidant capacity (TAC), homocysteine and folic acid levels, nutritional status, lifestyle, and socioeconomic variables in an adult population. A cross-sectional epidemiological study representative of the East and West regions of the municipality of João Pessoa, Paraíba state, Brazil, enrolled 265 adults of both genders.

α-Tocopherol influences glycaemic control and DNA methylation in overweight and obese women under an energy-restricted diet: a randomized, double-blind, exploratory, controlled clinical trial.

Background: Excess weight is a strong risk factor for the development of dysglycaemia. It has been suggested that changes in the metabolism microRNAs, small non-coding RNAs that regulate gene expression, could precede late glycaemic changes. Vitamin E in turn may exert important functions in methylation and gene expression processes.

Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults.

Background: DNA methylation has been evidenced as a potential epigenetic mechanism related to various candidate genes to development of obesity. Therefore, the objective of this study was to evaluate the DNA methylation levels of the ADRB3 gene by body mass index (BMI) in a representative adult population, besides characterizing this population as to the lipid profile, oxidative stress and food intake.

Methods: This was a cross-sectional population-based study, involving 262 adults aged 20-59 years, of both genders, representative of the East and West regions of the municipality of João Pessoa, Paraíba state, Brazil, in that were evaluated lifestyle variables and performed nutritional, biochemical evaluation and DNA methylation levels of the ADRB3 gene using high resolution melting method.

Influence of the C677T Polymorphism of the Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention.

The C677T polymorphism of the methylenetetrahydrofolate reductase gene () is related to folate metabolism and can alter the levels of biochemical markers.: Investigate the influence of the C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity.: Forty-eight adult women with overweight or obesity were subjected to a 24-hour dietary recall, anthropometric measurements, biochemical analysis, and genotyping of the C677T polymorphism.

Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the gene, lipid profile and oxidative stress in overweight or obese women.

Background: Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adrenergic receptor () responds to noradrenaline and mediates lipolysis in adipocytes.

Methods: This was a controlled intervention study involving 40 overweight and obese adult women in which food intake, anthropometric measurements, biochemical analyses, and methylation levels of the gene were evaluated before and after intervention.

[Measures of intergenerational transmission of obesity in Brazil].

A growing proportion of overweight individuals in Brazilian population highlights the importance of research in this area. Thus, this paper investigates the obesity problem from the point of view of intergenerational approach using Body Mass Index (BMI) of parents and their children. The information concerning BMI and socioeconomic control variables are obtained from the Household Budget Survey (POF) 2008-2009.