Publications by authors named "Alessio Finocchiaro"

Background: Socioeconomic status and geographical location contribute to disparities in localized prostate cancer (PCa) treatment. We examined the impact of area of deprivation index (ADI) on initial treatment type for localized PCa in a North-American cohort.

Methods: We performed a retrospective analysis of patients diagnosed with localized PCa, treated within Henry Ford Health (HFH), between 1995 and 2022, with available ADI-data.

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Background And Objective: Prostate cancer (PCa) is a significant global health concern, ranking as the second most prevalent cancer among men worldwide. Genetic factors, particularly germline pathogenic variants (PVs) in DNA repair genes (DRGs), play a crucial role in PCa predisposition. Our study aimed to assess patients' adherence to a targeted PCa screening program targeting high-risk individuals with DRG PVs and evaluate the potential reduction in biopsy and MRI rates by employing our screening protocol.

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Article Synopsis
  • Multiparametric magnetic resonance imaging (mpMRI) and microultrasound (micro-US) are both effective technologies for detecting significant prostate cancer, but they differ in their performance in biopsy-naïve patients with discordant lesions.
  • In a study of 178 men, micro-US-guided targeted biopsy (micro-US-TBx) showed a higher detection rate for clinically significant prostate cancer (csPCa) compared to mpMRI-guided targeted biopsy (MTBx), with 20% vs. 16% respectively.
  • The combination of mpMRI and micro-US improved detection rates for both clinically significant and clinically insignificant prostate cancer, indicating their synergistic value when used together.
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