Publications by authors named "Alessia Latini"
Coronary dissection is a potential occurrence after lesion preparation for percutaneous coronary intervention (PCI). Unlike stents, drug-coated balloons (DCB) do not allow to cover dissections, thus demanding an assessment of their safety in this setting. The aim of this study was to evaluate incidence, predictors, and clinical outcomes of dissections occurring with DCB-based PCI for de novo coronary artery disease (CAD).
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- Balloon-expandable valves (BEVs) and self-expanding valves (SEVs) are compared for their effects on patients with Sievers type 1 bicuspid aortic valve (BAV) stenosis undergoing transcatheter aortic valve replacement.
- The analysis, based on a registry of 955 patients, found no significant difference in midterm major adverse events or technical success between BEVs and SEVs after adjusting for baseline differences.
- However, BEVs had lower risks of new permanent pacemaker implantation and moderate or greater paravalvular regurgitation, but a higher risk of severe patient-prosthesis mismatch compared to SEVs.
Article Synopsis
- The study aimed to analyze the impact of gender on clinical outcomes after a 1-month dual-antiplatelet therapy (DAPT) period in patients at high bleeding risk undergoing percutaneous coronary intervention (PCI) with bioresorbable polymer everolimus-eluting stent (BP-EES).
- The research found that while women had additional risk factors such as older age and lower hemoglobin levels, they did not show a significantly higher risk for serious complications compared to men after the 1-month DAPT period.
- The results suggest that a short DAPT strategy post-PCI may be a safe and effective option for high bleeding risk women, indicating that sex may not be a critical factor in determining adverse outcomes in this context
Article Synopsis
- The study examines the characteristics and outcomes of patients with tapered raphe-type bicuspid aortic valve (BAV) when undergoing trans-catheter aortic valve replacement (TAVR), focusing on the safety and effectiveness of modern heart valves.
- Researchers analyzed data from 897 patients, finding that those with tapered configurations showed similar success rates and safety between two sizing strategies: annular and supra-annular.
- The results indicate that TAVR is a safe and effective procedure for these patients, regardless of the sizing method used, maintaining a high rate of clinical efficacy at mid-term follow-up.
Background: Enhanced characterization of the atrial electrical substrate may lead to better comprehension of atrial fibrillation (AF) pathophysiology.
Objective: With the use of high-density substrate mapping, we sought to investigate the occurrence of functional electrophysiological phenomena in the left atrium and to assess potential association with arrhythmia recurrences after catheter ablation.
Methods: Sixty-three consecutive patients with AF referred for ablation were enrolled.
Article Synopsis
- Atrial fibrillation (AF) is the most common arrhythmia after surgery, and this study aimed to find out how often it occurs (postoperative AF or POAF) and what factors predict it, especially focusing on inflammation markers like C-reactive protein (CRP).
- In a study with over 53,000 patients, POAF happened in 570 patients (1.1%), primarily occurring around 3.4 days post-surgery, with a notable link between higher CRP levels and the likelihood of developing POAF.
- The research found that patients undergoing lung and cardiovascular surgeries had the highest risk of POAF, indicating that surgery type and levels of inflammation are key predictors of this condition.
Article Synopsis
- Low-voltage area (LVA) ablation, combined with pulmonary vein isolation (PVI), is being studied as a treatment for atrial fibrillation (AF), but previous clinical trials have shown mixed results.
- A systematic review and meta-analysis of 1547 patients from 7 studies revealed that adding LVA ablation significantly reduced the chances of atrial arrhythmia recurrence after the first AF ablation procedure.
- The study found no significant differences in procedure time, fluoroscopy time, or complication rates between those receiving LVA ablation and those who did not.
Article Synopsis
- A study examined the effects of short dual antiplatelet therapy (S-DAPT) following percutaneous coronary intervention (PCI) in patients at high bleeding risk (HBR) using a specific heart health criteria (ARC-HBR).
- The research involved 356 patients with a high prevalence of risk factors, showing that 5.2% experienced serious cardiac events within 12 months, while 2.7% had significant bleeding complications.
- Findings suggest S-DAPT after using Synergy bioresorbable stents leads to favorable outcomes for both ischemic and bleeding events in high-risk patients, supporting previous positive results from the POEM trial.
Update on long-term cardiovascular risk after pre-eclampsia: a systematic review and meta-analysis.
Eur Heart J Qual Care Clin Outcomes
January 2024
Background/introduction: There is a need for further studies on the cardiovascular risk of women experiencing pre-eclampsia (PE).
Purpose: To update the literature regarding the association between a history of PE and subsequent cardiovascular diseases, including cardiovascular death, coronary heart diseases, heart failure, and stroke, focusing on the trend in the effect size (ES) estimates over time.
Methods And Results: Following PRISMA guidelines, from inception to May 2023, we performed a systematic review of PubMed, MEDLINE, Scopus, and EMBASE.
Article Synopsis
- * 443 patients were enrolled, with no significant differences in the rates of serious heart issues like cardiac death and heart attacks between the ACS and CCS groups after 12 months.
- * Both groups showed similar rates of bleeding complications, indicating that a 1-month DAPT approach is safe for HBR patients undergoing PCI with a specific type of stent (BP-EES).
Article Synopsis
- Transcatheter aortic valve replacement (TAVR) for severe native aortic valve regurgitation has shown suboptimal outcomes, particularly with older valve technologies; this study evaluates newer devices.
- The PANTHEON study analyzed 201 patients who received TAVR with both self-expanding and balloon-expandable valves, focusing on success rates and health outcomes after one year.
- Results revealed that while technical success was high, issues like transcatheter valve embolization occurred in a significant number of cases, indicating that TAVR still poses challenges despite advancements in valve technology.
The confirmation of a hypothesis that desmoplakin-related (DSP) cardiomyopathy could represent a distinct clinical entity from the classical, RV-dominant, form of arrhythmogenic cardiomyopathy (ACM), most frequently caused by PKP2 mutations, would without any shadow of doubt signify a turning point in the history of this disease. The concept of gene-specific diseases underneath the umbrella diagnosis of ACM would bring fundamental changes not only in the clinical, diagnostic and therapeutic approach, but also in terms of risk stratification, pushing the scientific community towards a more patient-centered view of the disease, similarly to what has already been done in other inherited arrhythmogenic disease (e.g.
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