Publications by authors named "Alessia Guarda"
Background: Home blood pressure telemonitoring figures among the possible solutions that could help improve blood pressure control of hypertensive patients. To summarize the effectiveness of home blood pressure telemonitoring on blood pressure control from randomized, controlled studies.
Methods: Electronic databases were searched for publications in English, reporting on randomized trials of home blood pressure telemonitoring vs.
Article Synopsis
- The nuclear membrane and lamina play crucial roles in regulating the genome and organizing chromosomes during interphase, highlighting their importance beyond just structural support.
- Epigenetic modifications, like DNA methylation, are vital for genome reprogramming and gene expression, with MeCP2 acting as a transcriptional repressor by recruiting histone deacetylases.
- This study reveals that MeCP2 interacts with the inner nuclear membrane protein LBR, which may explain how heterochromatin is positioned at the nuclear periphery.
MECP2 is an X-linked gene coding for a protein functioning as a transcriptional repressor. The protein MeCP2 (Methyl CpG-binding protein) is an abundant component of pericentric heterochromatin and its mutations or duplications are present in around 80% of patients with a neurological disorder known as Rett Syndrome. Although MeCP2 action depends critically on its binding to chromatin, very little is known about the dynamics of this process.
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