Publications by authors named "Alessia Furgiuele"
Article Synopsis
- Proinflammatory cytokines significantly increase the expression and activity of the enzyme indoleamine 2,3-dioxygenase-1 (IDO-1), which plays a key role in regulating T cell responses by converting tryptophan into L-kynurenine in dendritic cells and monocytes.
- An experimental setup involving isolated peripheral blood mononuclear cells (PBMCs) from healthy donors was used to assess IDO1's influence on lymphocyte proliferation under a pro-inflammatory environment triggered by lipopolysaccharide and anti-CD3/CD28.
- Results showed that while increased IDO1 activity correlated with reduced lymphocyte proliferation when tryptophan was introduced, inhibiting IDO1 did not affect
Article Synopsis
- Cannabidiol (CBD) is studied for its impact on immune responses, specifically how it influences proinflammatory cytokine production and T cell behavior in human peripheral blood mononuclear cells (PBMCs).
- The research analyzed CBD's effects on cytokine levels, cell proliferation, and regulatory T cell functionality, using techniques like flow cytometry and ELISA assays on isolated cells from healthy individuals.
- Results indicate that CBD decreases certain cytokine mRNA levels and alters T cell differentiation, but its role in Treg cell function and PBMC proliferation is complex, warranting further exploration.
Article Synopsis
- Parkinson's disease (PD) impacts 7-10 million people globally, with no existing treatments to halt or slow down its progression, largely due to a lack of understanding about how dopaminergic neuron death occurs.
- Current treatments mainly aim to compensate for dopamine deficiency in the brain but don't adequately address the underlying disease mechanisms.
- Recent research highlights the immune system's role in PD, suggesting that targeting immune pathways could improve treatment outcomes alongside existing dopaminergic therapies.
Background: Dysregulation of the CD4 + T cell compartment occurs in Parkinson's Disease (PD). Nonetheless, the exact relationship with dopamine transporter (DAT) SPECT denervation patterns is currently unknown.
Methods: Expression of transcription factors and levels of circulating CD4 + T cell subsets were assessed in peripheral blood mononuclear cells (PBMC) from 23 newly diagnosed drug-naïve PD patients.
Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor symptoms, and treatment relies on dopaminergic replacement. Beyond a common pathological hallmark, PD patients may present differences in both clinical progression and response to drug therapy that are partly affected by genetic factors.
View Article and Find Full Text PDFImmunomodulatory Potential of Cannabidiol in Multiple Sclerosis: a Systematic Review.
J Neuroimmune Pharmacol
June 2021
Multiple sclerosis (MS) is the most common chronic autoimmune disease of the central nervous system. Efficacy of treatments for MS is associated with risk of adverse effects, and effective and well-tolerated drugs remain a major unmet need. Cannabis (Cannabis sativa L.
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