Mitigating Interobserver Variability in Radiomics with ComBat: A Feasibility Study.

This study investigates Intraobserver Features Variability (IFV) in radiomics studies and assesses the effectiveness of the ComBat harmonization method in mitigating these effects. This study utilizes data from the NSCLC-Radiomics-Interobserver1 dataset, comprising CT scans of 22 Non-Small Cell Lung Cancer (NSCLC) patients, with multiple Gross Tumor Volume (GTV) delineations performed by five radiation oncologists. Segmentation was completed manually ("vis") or by autosegmentation with manual editing ("auto").

Is it still necessary to perform measured based pre-treatment patient-specific QA for SRS HyperArc treatments?

Purpose: The Mobius3D system was validated as a modern secondary check dosimetry system. In particular, our objective has been to assess the suitability of the M3D as pre-treatment patient-specific Quality Assurance (QA) tool for Stereotactic Radiosurgery (SRS) HyperArc (HA) treatments. We aimed to determine whether Mobius3D could safely replace the measurements-based patient-specific QA for this type of treatment.

Organ dose in CT: Comparison between measurements and computational methods.

Purpose: This study aims to compare two methods for the organ dose evaluation in computed tomography (CT) in the head- and thorax regions: an experimental method, using radiochromic films, and a computational one, using a commercial software.

Methods: Gafchromic® XR-QA2 and EBT-3 were characterized in terms of energetic, angular, and irradiation configurations dependence. Two free-in-air irradiation calibration configurations were employed using a CT scanner: with the sensitive surface of the film orthogonal (OC) and parallel (PC) to the beam axis.

HyperArc Dosimetric Validation for Multiple Targets Using Ionization Chamber and RT-100 Polymer Gel.

Multiple brain metastases single-isocenter stereotactic radiosurgery (SRS) treatment is increasingly employed in radiotherapy department. Before its use in clinical routine, it is recommended to perform end-to-end tests. In this work, we report the results of five HyperArcTM treatment plans obtained by both ionization chamber (IC) and polymer gel.