Publications by authors named "Alessia Centonze"
Glandular epithelia, including mammary gland (MG) and prostate, are composed of luminal and basal cells. During embryonic development, glandular epithelia arise from multipotent stem cells (SCs) that are replaced after birth by unipotent basal and unipotent luminal SCs. Different conditions, such as basal cell transplantation, luminal cell ablation, and oncogene expression can reinduce adult basal SC (BaSCs) multipotency in different glandular epithelia.
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- Cold exposure activates sympathetic nerves that increase fat cell (adipocyte) thermogenesis through a protein called uncoupling protein 1 (UCP1), which varies by sex and fat location.
- Mammary gland duct cells in female mice influence UCP1 expression in subcutaneous white adipose tissue (scWAT) by releasing factors called 'mammokines.'
- Research shows that these mammokines, particularly lipocalin 2, can limit UCP1 expression, resulting in lower fat oxidation and energy expenditure in females compared to males, highlighting sex-specific differences in fat metabolism.
Article Synopsis
- Glandular epithelia, like mammary and prostate glands, consist of basal cells (BCs) and luminal cells (LCs), with adult basal stem cells (BSCs) having limited multipotency under normal conditions.
- When LCs are removed, BSCs can regain their multipotency and follow a differentiation program akin to embryonic development, as shown through RNA sequencing.
- The study reveals that LCs communicate with BSCs, primarily through TNF signaling, to maintain the restricted multipotency of BSCs, highlighting the importance of this interaction for proper stem cell function in glandular tissues.
In the version of this Article originally published, ref. 52 was incorrectly only attributed to its corresponding author, Fre, S., and an older title was used.
View Article and Find Full Text PDFThe mammary gland is composed of basal cells and luminal cells. It is generally believed that the mammary gland arises from embryonic multipotent progenitors, but it remains unclear when lineage restriction occurs and what mechanisms are responsible for the switch from multipotency to unipotency during its morphogenesis. Here, we perform multicolour lineage tracing and assess the fate of single progenitors, and demonstrate the existence of a developmental switch from multipotency to unipotency during embryonic mammary gland development.
View Article and Find Full Text PDFThe mammary gland (MG) is composed of different cell lineages, including the basal and the luminal cells (LCs) that are maintained by distinct stem cell (SC) populations. LCs can be subdivided into estrogen receptor (ER) and ER cells. LCs act as the cancer cell of origin in different types of mammary tumors.
View Article and Find Full Text PDFIn colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely limits availability of preclinical models for in-depth characterization. Using a pipeline designed to suppress stroma-derived signal, we find that RSPO3 "outlier" expression in CRC samples highlights translocation and fusion transcript expression.
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