Publications by authors named "Alessia Berbiglia"
, also known as Group B or GBS, is a commensal colonizer of human vaginal and gastrointestinal tracts that can also be a deadly pathogen for newborns, pregnant women, and the elderly. The SaeRS two-component regulatory system (TCS) positively regulates the expression of two GBS adhesins genes, but its role in the formation of biofilm, an important step in pathogenesis, has not been investigated. In the present study, we set up a novel model of GBS biofilm formation using surfaces coated with human fibrinogen (hFg).
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- - Group B Streptococcus (GBS) can switch from being harmless to causing serious infections, particularly in newborns and the elderly, based on how it manages its virulence factors.
- - The study focuses on the SaeRS two-component system, which helps regulate the expression of specific virulence factors that allow GBS to invade host cells and persist during infections.
- - Findings show that while activating SaeRS can enhance GBS's ability to adhere to and invade host tissues, it may reduce overall virulence, highlighting the complex balance in bacterial pathogenesis.