Publications by authors named "Alessia Anselmi"
HIV-1 infection causes a severe T-cell impairment with alteration of immune response. However, in children the natural decline of lymphocytes and CD4 cells in early life makes it more difficult to monitor immunocompetence and progression of HIV-infection. Aim of this study was to characterize the CD8 response in non-vertically HIV-infected children exposed persistently to viremia and in HIV-infected children controlling efficiently viremia by ART, by analysing the effect of persistent viremia on CD4 and CD8 T-cells count, HIV-specific immune-response and naive/memory pattern of CD8 T-cell.
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- Early antiretroviral therapy (ART) initiated within 3 months of age in HIV-1-infected infants significantly reduces plasma viral loads to undetectable levels, indicating effective control of HIV replication.
- Despite this, some children still had residual HIV-1 DNA and only a couple developed HIV-1 antibodies, while others remained seronegative after losing maternal immunity.
- Overall, while early ART helps manage the infection and lowers viral loads, it doesn't eliminate latent infected cell reservoirs, making complete virus eradication challenging.