Publications by authors named "Alessandro Giampietro"
Article Synopsis
- DNA damage is identified as a significant contributor to heart disease, particularly involving cardiomyocytes and smooth muscle cells, though the details are not fully understood.
- Research focused on a factor called Ft1 in mice and AKTIP in humans, revealing that its depletion leads to telomere instability and DNA damage, impacting heart health.
- Two mouse models with varying Ft1 depletion showed that both developed cardiac issues like hypertrophy and fibrosis, but the smooth muscle-targeted model exhibited milder, age-exacerbated symptoms, suggesting Ft1 deficiency is a key factor in cardiac disease progression.
