Publications by authors named "Alessandro Francesco Ulivi"
Article Synopsis
- The study investigates how stress-related psychiatric disorders differ between males and females, focusing on transcriptional changes in the brain's stress response system.
- Through single-cell RNA sequencing, researchers uncover unique cellular responses to acute stress in the hypothalamus of male and female mice.
- The findings reveal that chronic mild stress modifies these cellular responses in a sex-specific manner, highlighting oligodendrocytes as key players in this process, with available data provided through an interactive online app for further research.
The G protein-coupled receptor 17 (GPR17) plays crucial roles in myelination. It is highly expressed during transition of oligodendrocyte progenitor cells to immature oligodendrocytes, but, after this stage, it must be down-regulated to allow generation of mature myelinating cells. After endocytosis, GPR17 is sorted into lysosomes for degradation or recycled to the plasma membrane.
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