Publications by authors named "Alessandro De Carli"

Article Synopsis
  • The study investigates how Matrix Support (MS) affects integration between Primary Health Care (PHC) and Dental Specialty Centers (CEOs) in Brazil.
  • Findings reveal that nearly half of the CEOs lack collaborative therapeutic projects with PHC oral health teams, which is linked to various factors like poor case discussions and absence of joint educational activities.
  • The conclusion emphasizes that individual practices within CEOs play a more significant role in the integration issues than broader contextual factors from local municipalities.
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Objective: The aim of this study was to investigate, at a national level, which individual factors of the work process/infrastructure are associated with the achievement of goals in the periodontics specialty in Brazilian Dental Specialty Centers (BDSC).

Methods: This was a quantitative, analytical, cross-sectional study. Secondary data from DATASUS and the external evaluation of the second cycle of the BDSC Access and Quality Improvement Program were used.

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The field of probiotic applications is rapidly expanding, including their use for the control of respiratory tract infections. Nevertheless, probiotics ability to colonize the lung environment and to compete with pulmonary pathogens is still a poorly investigated research area. In this study, we aimed to evaluate the adhesion ability of a number of commercial probiotic strains to the human lung epithelial cell line A549.

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Recent evidence suggests that lipids play a crucial role in viral infections beyond their traditional functions of supplying envelope and energy, and creating protected niches for viral replication. In the case of Zika virus (ZIKV), it alters host lipids by enhancing lipogenesis and suppressing β-oxidation to generate viral factories at the endoplasmic reticulum (ER) interface. This discovery prompted us to hypothesize that interference with lipogenesis could serve as a dual antiviral and anti-inflammatory strategy to combat the replication of positive sense single-stranded RNA (ssRNA+) viruses.

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Background: This systematic review and network meta-analysis aimed to compare the clinical efficacy of bioactive and conventional restorative materials in controlling secondary caries (SC) and to provide a classification of these materials according to their effectiveness.

Methods: A search was performed in Pubmed, Web of Science, Embase, BBO, Lilacs, Cochrane Library, Scopus, IBECS and gray literature. Clinical trials were included, with no language or publication date limitations.

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Article Synopsis
  • Timely diagnosis of oral cancers is essential, and the study focuses on understanding factors affecting waiting times for oral biopsies in Brazil.
  • The research utilized secondary data to analyze the scheduling of biopsies and identified that 51.8% of dental specialty centers had non-immediate waiting times.
  • The study concluded that longer waiting times are linked to coverage provided by dental centers, particularly those serving only one municipality, while other contextual factors were not significant.
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Mechanisms underlying vascular endothelial susceptibility to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not fully understood. Emerging evidence indicates that patients lacking von Willebrand factor (vWF), an endothelial hallmark, are less severely affected by SARS-CoV-2 infection, yet the precise role of endothelial vWF in modulating coronavirus entry into endothelial cells is unknown. In the present study, we demonstrated that effective gene silencing by short interfering RNA (siRNA) for vWF expression in resting human umbilical vein endothelial cells (HUVECs) significantly reduced by 56% the cellular levels of SARS-CoV-2 genomic RNA.

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A marked reorganization of internal membranes occurs in the cytoplasm of cells infected by single stranded positive-sense RNA viruses. Most cell compartments change their asset to provide lipids for membrane rearrangement into replication organelles, where to concentrate viral proteins and enzymes while hiding from pathogen pattern recognition molecules. Because the endoplasmic reticulum is a central hub for lipid metabolism, when viruses hijack the organelle to form their replication organelles, a cascade of events change the intracellular environment.

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Objective: The objective of the present study was to analyse the quality of adults and older adults health care in Primary Health Care (PHC) services in the State of Mato Grosso do Sul, 2018.

Methods: A quantitative survey was carried out in which the municipalities participating in the study included the four macro-regions following the Director Regional Plan (DRP). In this study, the quality of care was verified using the validated version of the PCAT-Br for adult and older adults users over 18 years of age and professionals.

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Background: Brazil experienced an expansion of the population's access to oral health policies after the creation of the Unified Health System (SUS, Sistema Único de Saúde). Through public policies, the consolidation of Primary Health Care (PHC) and the incorporation of dental care into primary and hospital care took place. The objective of this study was to identify epidemiological aspects, including the temporal trend, of hospital morbidity from oral and oropharyngeal cancer in Brazil, considering hospitalizations for this neoplasm in a hospital network linked to the public care system.

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Background: Congenital syphilis (CS) is a problem of great concern for public health, especially in Brazil. The aim of this study was to analyse the time trends and the space-time dynamics of morbidity and mortality from CS in Brazil.

Methods: An ecological and time series study, which included all cases and deaths from CS recorded in a national Brazilian database from 2013 to 2019 was performed.

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Background: Integrated dental services within the Health System, particularly at primary health care, are crucial to reverse the current impact of oral diseases, which are among the most prevalent diseases worldwide. However, the use of dental services is determined by complex phenomena related to the individual, the environment and practices in which care is offered. Therefore, factors associated with dental appointments scheduling can affect positively or negatively the use of dental services.

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Background: Oral and oropharyngeal cancers are considered important public health problems worldwide. This study aims to analyze the association between late diagnosis of oral and oropharyngeal cancers in Brazil and the contextual indicators of socioeconomic variables and coverage of Primary Health Care (PHC), and to assess the temporal trend of late diagnosis.

Methods: In this cross-sectional observational study, secondary data were evaluated with a time series analysis.

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Article Synopsis
  • Chikungunya fever, transmitted mainly by Aedes mosquitoes, significantly affects patients' quality of life, with unclear oral manifestations that the study aims to clarify.
  • A systematic review analyzed 27 studies, highlighting various oral issues like ulcers, gingival bleeding, and changes in taste which primarily cause discomfort during chewing.
  • The findings suggest that these oral symptoms are more common in women and older adults, typically easing within 3 to 10 days, and are linked to viral infections and an inflammatory response.
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Objective: This study investigated whether the presence of care workers who completed a specialization course on family health was associated with improved care and maternal and child health indicators in municipalities in the state of Mato Grosso do Sul, Brazil.

Methods: Negative binomial regression models with fixed effects were used for the 79 municipalities in the state of Mato Grosso do Sul, with repeated observations for the period 2009-2015. For our reference, the parameter "number of professionals who completed the course" calculated the proportion of professionals who completed the course, and was divided by the total number of primary health care professionals in the municipality to create a ratio.

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Objective: The objective of this study was to verify whether the inclusion of professionals who completed a specialized distance learning course in family health teams is associated with rates of hospitalization for primary healthcare-sensitive conditions and better monitoring of chronic conditions in municipalities within the state of Mato Grosso do Sul, Brazil.

Methods: Negative binomial regression models with fixed effects were used for the 79 municipalities in the state, with repeated observations for the selected years (2009-2015). For our reference, the parameter "Municipality Ratio" was the number of professionals who completed the course divided by the total number of PHC professionals in the municipality.

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Studies on the impacts of drought usually make the implicit assumption that there will always be a negative effect on the environment, the economy and society. However, other approaches, based for example on the framework provided by the consumer surplus theory, try to focus on the distributive effects of drought. In this paper, in the wake of such approaches, we address the question of the distributive effects of drought on agriculture, exploring and studying in depth the characteristics, the signs and the magnitude of the socio-economic impacts of droughts on specific significant agricultural areas in Europe.

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Article Synopsis
  • - The study aimed to find out what individual and contextual factors influence elderly Brazilians' self-perceived need for dental treatment and prostheses, using data from a large national health survey.
  • - Data from 7,619 elderly participants showed that about half felt they needed dental treatment, while over half thought they needed prostheses, with significant factors including gender, skin color, income, and access to oral health services.
  • - The findings indicated that individual factors played a major role in how elderly Brazilians perceive their dental treatment needs, highlighting social inequalities and helping to inform health service planning.
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Article Synopsis
  • * The most common focus of these articles was the implementation of oral health teams, which made up 18% of the identified themes, with the Northeast of Brazil contributing the most articles (61 total).
  • * Findings showed a trend towards quantitative research and highlighted a growing interest in understanding how oral health is integrated into primary care, especially concerning professional roles and teamwork dynamics.
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Background: Tutored laboratorial activities could be a manner of improving the competency development of students. However, its impact over conventional theoretical classes has not yet been tested. Additionally, different university contexts could influence this issue and should be explored.

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Article Synopsis
  • Dental trauma is a significant public health issue among 12-year-old children in Brazil, with a prevalence rate of 23.96%, and factors like sociodemographic background and occlusal problems play key roles in its occurrence.
  • Female children showed lower risk for traumatic outcomes, while non-white children faced higher risks for specific injuries like maxillary tooth fractures.
  • The study highlights that traumatic dental injuries negatively affect oral health-related quality of life and suggests promoting preventive measures like mouthguard use through family and school health initiatives.
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Objective: To assess the relationship between periodontal treatment needs by elderly Brazilians and contextual as well as individual variables.

Methods: A cross-sectional study was carried out to assess the need for clinical periodontal treatment, based on National Oral Health Survey (SB Brasil 2010) data on the presence of dental calculus, shallow (3-5 mm) and deep (≥ 6 mm) periodontal pockets, and gingival bleeding in elderly people (n = 7,619). The contextual variables included the Municipal Human Development Index (MHDI), income inequality (Gini Index) and coverage of the municipal population by the Family Health Strategy (FHS) program oral health teams.

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A critical assumption of studies assessing comparatively waste management options concerns the constant average cost for selective collection regardless the source separation level (SSL) reached, and the neglect of the mass constraint. The present study compares alternative waste management scenarios through the development of a desktop model that tries to remove the above assumption. Several alternative scenarios based on different combinations of energy and materials recovery are applied to two imaginary areas modelled in order to represent a typical Northern Italian setting.

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The objective of this study was to analyze the fluoride concentration on the water that flows of the tap in the urban area of the city of Campo Grande (MS). For the fluoride concentration analysis, it was collected water samples of 21 schools placed in the 7 sub districts of the city, in 3 different opportunities, was made by the specific electrode method (using an Orion 9609 BN combined fluoride measuring electrode, coupled with an Orion EA-940 digital potentiometer). The results showed that 63.

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