Publications by authors named "Alessandro Cormace"
Int J Mol Sci
August 2023
Article Synopsis
- AR expression in ER+ breast cancer is linked to lower tumor grades and improved clinical outcomes, suggesting a protective role in tumor progression.
- Androgens activate the androgen receptor, which increases levels of the protein BAD, enhancing its presence in both the nucleus and mitochondria, further supporting its role as a cell cycle inhibitor.
- BAD interacts with the androgen receptor in the nucleus, influencing cyclin D1 promoter activity, while its localization in mitochondria is associated with reduced mitochondrial function, contributing to the anti-proliferative effects of androgens in breast cancer cells.
