Bgee in 2024: focus on curated single-cell RNA-seq datasets, and query tools.

Bgee (https://www.bgee.org/) is a database to retrieve and compare gene expression patterns in multiple animal species.

Editorial for the Special Issue on Flexible Micromanipulators and Micromanipulation.

The field of micromanipulation is rapidly growing and evolving thanks to advancements in microfabrication technologies and the increased demand for precise and accurate manipulation of microscale objects [...

Dynamic Model of a Conjugate-Surface Flexure Hinge Considering Impacts between Cylinders.

A dynamic model of a Conjugate-Surface Flexure Hinge (CSFH) has been proposed as a component for MEMS/NEMS Technology-based devices with lumped compliance. However, impacts between the conjugate surfaces have not been studied yet and, therefore, this paper attempts to fill this gap by proposing a detailed multibody system (MBS) model that includes not only rigid-body dynamics but also elastic forces, friction, and impacts. Two models based on the Lankarani-Nikravesh constitutive law are first recalled and a new model based on the contact of cylinders is proposed.

Dynamic assessment of the risk of airborne viral infection.

This paper applies the Rudnick and Milton method through the dynamic evaluation of the probability of airborne contagion, redefining all parameters and variables in discretized form. To adapt the calculation of the risk of contagion to real needs, scenarios are used to define the presence of people, infected subjects, the hourly production of the quanta of infection, and the calculation of the concentration of CO produced by exhalation in the air. Three case studies are discussed: a school, an office, a commercial activity.

Individual patient data systematic review and meta-analysis of optic nerve sheath diameter ultrasonography for detecting raised intracranial pressure: protocol of the ONSD research group.

Background: The purpose of the optic nerve sheath diameter (ONSD) research group project is to establish an individual patient-level database from high quality studies of ONSD ultrasonography for the detection of raised intracranial pressure (ICP), and to perform a systematic review and an individual patient data meta-analysis (IPDMA), which will provide a cutoff value to help physicians making decisions and encourage further research. Previous meta-analyses were able to assess the diagnostic accuracy of ONSD ultrasonography in detecting raised ICP but failed to determine a precise cutoff value. Thus, the ONSD research group was founded to synthesize data from several recent studies on the subject and to provide evidence on the diagnostic accuracy of ONSD ultrasonography in detecting raised ICP.

Ocular ultrasound to detect intracranial hypertension in trauma patients.

Background: Increases in intracranial pressure (ICP) after head trauma require a rapid recognition to allow for adequate treatments. The aim of this study was to determine whether dilation of the optic nerve sheath, as detected by ocular ultrasound at the bedside, could reliably identify increases in ICP assessed with an intraparenchymal probe in adult head trauma patients.

Methods: Eleven head trauma injured adult patients admitted to the intensive care unit with a Glasgow Coma Scale score ≤8, with cerebral contusion confirmed by computed tomography scan, and that required invasive ICP monitoring, were enrolled in the study.