Publications by authors named "Alessandro Alvaro"

Article Synopsis
  • The study focuses on an opportunistic pathogen that thrives in harsh environments and often leads to outbreaks in neonatal intensive care units (NICUs), primarily caused by a specific clone, referred to as the "Infectious clone."
  • It introduces a new method called hypervariable-locus melting typing (HLMT) that allows rapid detection and typing of this pathogen without the need for cultivation, achieving high accuracy with 97% specificity and 96% sensitivity compared to traditional whole genome sequencing (WGS).
  • The HLMT protocol is advantageous for large-scale environmental and clinical screenings, offering cost and time efficiency that is particularly beneficial in low- to middle-income countries.
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Purpose: Myiases are infestations of human and animal tissues by fly larvae. These conditions are widespread in tropical countries and travelers in those areas are at risk of becoming infested. Although Cordylobia anthropophaga (Blanchard & Berenger-Feraud, 1872) is one of the most common myiasis-causing species, few high-quality images and molecular sequences are available for this fly.

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Parasites of the genus Leishmania are unusual unicellular microorganisms in that they are characterized by the capability to subvert in their favor the immune response of mammalian phagocytes, including dendritic cells. Thus, in overt leishmaniasis, dendritic cells and macrophages are converted into a niche for Leishmania spp. in which the parasite, rather than being inactivated and disassembled, survives and replicates.

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DNA methylation is an important mechanism involved in bacteria limiting foreign DNA acquisition, maintenance of mobile genetic elements, DNA mismatch repair, and gene expression. Changes in DNA methylation pattern are observed in bacteria under stress conditions, including exposure to antimicrobial compounds. These changes can result in transient and fast-appearing adaptive antibiotic resistance (AdR) phenotypes, e.

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Pathogen typing is pivotal to detecting the emergence of high-risk clones in hospital settings and to limit their spread. Unfortunately, the most commonly used typing methods (i.e.

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The aim of this review was to provide a general overview to the topic of this special issue. In this study the available categories of biotics were defined (i.e.

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Mortality in neonates with Gram-negative bloodstream infections has remained unacceptably high. Very few data are available on the impact of resistance profiles, virulence factors, appropriateness of empirical treatment and clinical characteristics on patients' mortality. A survival analysis to investigate 28-day mortality probability and predictors was performed including (I) infants <90 days (II) with an available Enterobacterales blood isolate with (III) clinical, treatment and 28-day outcome data.

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