Synopsis of recent research by authors named "Alessandria Greco"
- Alessandria Greco's recent research focuses on the safety and efficacy of adeno-associated virus (AAV) gene therapies for severe genetic disorders, particularly CLN2 Batten disease, Friedreich's ataxia, and α1-antitrypsin deficiency.
- The studies demonstrate that increasing levels of the deficient proteins (TPP-1, frataxin, and α1-antitrypsin) in the central nervous system and other target areas could potentially ameliorate disease symptoms and improve patient outcomes.
- Greco's findings emphasize the importance of ensuring a safe biodistribution and effective dosing strategies of AAV vectors when administered intravenously or via other routes, paving the way for potential future clinical applications in treating these life-threatening conditions.
