Publications by authors named "Alessandra Tolva"
Article Synopsis
- Classical Hodgkin lymphoma is a type of cancer that usually affects young people and has a good chance of being treated successfully.
- People who survive the disease may still face problems like getting other cancers, heart issues, or having trouble having kids, which can affect their lives.
- Researchers are looking at different treatment methods to make sure they are safer and cost-effective, especially considering the use of new treatments like proton therapy.
Background: Immune thrombocytopenia (ITP) is an acquired immune-mediated bleeding disorder characterized by isolated thrombocytopenia. Its estimated yearly incidence in the pediatric population is 1.9-6.
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- - This multicenter retrospective study investigated the effects of eltrombopag treatment in Italian children with chronic ITP, analyzing data from 56 patients across 17 centers.
- - Patients were divided into three groups based on their treatment outcomes: those who stopped due to stable platelet counts, those who stopped due to ineffectiveness, and those who continued treatment.
- - Results showed that 36% of patients stopped eltrombopag permanently, mainly due to inefficacy, but those who had stable platelet counts maintained improvement without further treatment, highlighting the significance of early treatment response.
Fatigue perception in a cohort of children with chronic immune thrombocytopenia and their caregivers using the PedsQL MFS: Real-life multicenter experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP).
Pediatr Blood Cancer
March 2021
Background: Fatigue is an important clinical and psychological aspect for a significant number of children affected by immune thrombocytopenia (ITP). To date, few studies have explored fatigue and its relationship with chronic ITP in pediatric age. The aim of the present multicentric pilot study is to determine fatigue perception in a large group of children with chronic ITP and their caregivers using the PedsQL Multidimensional Fatigue Scale (PedsQL MFS), and to compare the results with those of healthy control subjects.
View Article and Find Full Text PDFThe thrombopoietin receptor agonist eltrombopag has been shown to be safe and effective for children with chronic immune thrombocytopenia (ITP). The aim of the present study was to characterize eltrombopag use in current clinical practice. This is a retrospective multicenter study conducted in 17 centers affiliated to the Italian Association of Pediatric Hematology and Oncology (AIEOP).
View Article and Find Full Text PDFBackground: Immune thrombocytopenia (ITP) is an acquired immune-mediated disorder characterized by isolated thrombocytopenia. Pediatric ITP patients are prone to develop autoantibodies such as antithyroglobulin (TG) and antithyroperoxidase (TPO), even in the absence of clinical signs of autoimmune disease. The aim of this multicenter retrospective study was to evaluate (1) the prevalence of positivity of antithyroid antibodies (TPO and TG) in a large cohort of pediatric patients with chronic ITP; (2) the role of autoimmune thyroiditis as a prognostic factor for chronicity of ITP.
View Article and Find Full Text PDFHematopoietic stem cell transplantation (HSCT) is the only therapy for a subset of patients with malignant and nonmalignant diseases. Central nervous system (CNS) complications continue to be an important cause of morbidity and significantly contribute to mortality after HSCT. These complications include infections, cerebrovascular lesions, therapy-induced diseases, metabolic disturbances, and post-HSCT carcinogenesis.
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