Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides.

In recent years, the "Escape-from-Flatland" trend has prompted the synthetic community to develop a set of cross-coupling strategies to introduce sp-carbon-based fragments in organic compounds. This study presents a novel nickel-catalyzed electrochemical methodology for reductive cross-electrophile coupling. The method enables C(sp)-C(sp) linkages using inexpensive amine-derived radical precursors and aryl iodides.

Nanostructured Carbon Nitride for Continuous-Flow Trifluoromethylation of (Hetero)arenes.

Efficient catalytic methods for the trifluoromethylation of (hetero)arenes are of particular importance in organic and pharmaceutical manufacturing. However, many existing protocols rely on toxic reagents and expensive or sterically hindered homogeneous catalysts. One promising alternative to conduct this transformation involves the use of carbon nitride, a non-toxic photocatalyst prepared from inexpensive precursors.

Structural Effects of Metal Single-Atom Catalysts for Enhanced Photocatalytic Degradation of Gemfibrozil.

The development of efficient catalysts is a highly necessary but challenging task within the field of environmental water remediation. Single-atom catalysts are promising nanomaterials within this respect, but in-depth studies encompassing this class of catalysts remain elusive. In this work, we systematically study the degradation of gemfibrozil, a persistent pollutant, on a series of carbon nitride photocatalysts, investigating both the effect of (i) catalyst textural properties and (ii) metal single atoms on the contaminant degradation.

Gram-Scale Domino Synthesis in Batch and Flow Mode of Azetidinium Salts.

Azetidinium salts are important motifs in organic synthesis but are difficult to obtain due to extremely long synthetic protocols. Herein, a rapid continuous-flow process for the on-demand synthesis of azetidinium salts is described. In particular, the nucleophilic addition of secondary amines and the subsequent intramolecular N-cyclization have been investigated in batch and continuous-flow modes, exploring the effects of solvent type, temperature, reaction time, and amine substituent on the synthesis of azetidinium salts.

Flow Microreactor Technology for Taming Highly Reactive Chloroiodomethyllithium Carbenoid: Direct and Chemoselective Synthesis of α-Chloroaldehydes.

A straightforward flow synthesis of α-chloro aldehydes has been developed. The strategy involves, for the first time, the thermal unstable chloroiodomethyllithium carbenoid and carbonyl compounds. A batch versus flow comparative study showcases the superb capability of flow technology in prolonging the lifetime of the lithiated carbenoid, even at -20 °C.