Impact of visceral fat on blood pressure and insulin sensitivity in hypertensive obese women.

Objective: The relationship among body fat distribution, blood pressure, serum leptin levels, and insulin resistance was investigated in hypertensive obese women with central distribution of fat.

Research Methods And Procedures: We studied 74 hypertensive women (age, 49.8 +/- 7.

Effects of sibutramine on the treatment of obesity in patients with arterial hypertension.

Objective: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months.

Methods: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo.

Results: The group using sibutramine had a greater weight loss than that using placebo (6.