Publications by authors named "Alessandra Grossert"
Article Synopsis
- Ketamine, an NMDA receptor antagonist, shows potential for treating major depressive disorder, even in cases resistant to other treatments, although its exact mechanism of action is not fully understood.
- The study utilized human induced pluripotent stem cells to explore how ketamine affects neural progenitor cells, finding that it promotes their proliferation independently of the NMDA receptor and increases levels of specific proteins associated with depression.
- Ketamine enhances cAMP signaling and IGF2 expression, leading to proliferation in the short term and showing cellular signaling changes in the brains of mice 24 hours after administration.
Nordihydroguaiaretic acid (NDGA) is the major lignan of the creosote bush Larrea tridentata known for its antioxidative and pharmacological properties. Here we present the identification of glucansucrases for NDGA glucosylation and the physicochemical and biological characterization of the glucosides. Extracellular glucansucrase of L.
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