Prolactin is Expressed in Uterine Leiomyomas and Promotes Signaling and Fibrosis in Myometrial Cells.

Uterine leiomyomas are benign, estrogen-sensitive, fibrotic smooth muscle cell tumors occurring in the uterine myometrium. Leiomyomas are a considerable health burden, with a lifetime prevalence of 80% and limited treatment options. Estrogen and progesterone have positive effects on leiomyoma growth, but little is known about the roles of other hormones.

Bilateral Pheochromocytomas in a Patient with Y175C Von Hippel-Lindau Mutation.

Von Hippel-Lindau (VHL) disease, caused by germline mutations in the gene, is characterized by metachronously occurring tumors including pheochromocytoma, renal cell carcinoma (RCC), and hemangioblastoma. Although VHL disease leads to reduced life expectancy, its diagnosis is often missed and tumor screening guidelines are sparse. VHL protein acts as a tumor suppressor by targeting hypoxia-inducible factors (HIFs) for degradation through an oxygen-dependent mechanism.

Left ventricular free-wall plication for ischemic cardiomyopathy: safe and effective?

In 10 patients, a free-wall plication of inferior or lateral scar was performed. The procedure was done on cardiopulmonary bypass and aortic cross-clamping by means of four or five wide U-stitches. Six patients underwent concomitant mitral annuloplasty and one mitral valve replacement.