Publications by authors named "Alessandra Della Porta"

From previous studies, we have shown that viable colony forming units of bacteria and bacterial biofilms are reduced after sequential treatment with a surfactant-based dressing. Here, we sought to test the impact on visible bacterial pigments and the ultrastructural impact following the sequential treatment of the same surfactant-based dressing. Mature Pseudomonas aeruginosa biofilms were grown on ex vivo porcine skin explants, and an imaging-based analysis was used to compare the skin with and without a concentrated surfactant.

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to create a structured approach for emergency medicine (EM) research that considers the social and structural factors affecting vulnerable populations, specifically through a scoping review and consensus-building process.
  • A scoping review identified 291 articles on structural competency and vulnerability, with 123 relevant to EM, providing insights into how to address health inequities in research.
  • The developed framework is a starting point for EM researchers to better integrate structural competency into their work, focusing on systemic issues rather than just individual factors contributing to health disparities.
View Article and Find Full Text PDF

Introduction: Social emergency medicine (EM) is an emerging field that examines the intersection of emergency care and social factors that influence health outcomes. We conducted a scoping review to explore the breadth and content of existing research pertaining to social EM to identify potential areas where future social EM research efforts should be directed.

Methods: We conducted a comprehensive PubMed search using Medical Subject Heading terms and phrases pertaining to social EM topic areas (e.

View Article and Find Full Text PDF

Background: Epinephrine is recommended in contemporary educational efforts by the American Heart Association (AHA) as central to adult Advanced Cardiac Life Support (ACLS). However, the International Liaison Committee on Resuscitation (ILCOR) 2019 recommendations update describes large evidentiary gaps for epinephrine use in cardiopulmonary resuscitation, highlighting that clinical and experimental evidence do not support the current AHA recommendations.

Objective: This controversies article was written as a response to updated AHA and ILCOR adult ACLS recommendations in late 2019.

View Article and Find Full Text PDF
Article Synopsis
  • Acute chloroquine and hydroxychloroquine toxicity leads to serious cardiovascular issues and electrolyte imbalances, resulting in potentially fatal dysrhythmias.
  • This toxicity is particularly concerning given the drugs' narrow therapeutic range and their increased usage, especially during the COVID-19 pandemic.
  • Emergency department management focuses on stabilizing patients through decontamination, correcting electrolyte imbalances, and providing cardiac support to reduce morbidity and mortality.
View Article and Find Full Text PDF

Bacterial biofilms have been found in many, if not all, chronic wounds. Their excessive extracellular matrix secretion and the metabolic changes that they undergo render them highly tolerant of many antibiotic and antimicrobial treatments. Physical removal and/or disruption are a common approach to treating wounds suspected of having bacterial biofilms.

View Article and Find Full Text PDF