Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice.

Purpose: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia.

Methods: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-N-nitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz).

Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis.

Objective: To examine the impact of a recent surgery on development of endometriosis-related adhesions in a chimeric model and to determine the therapeutic efficacy of pioglitazone (PIO).

Design: Human endometrial biopsies were maintained in E(2) with or without PIO for 24 h before intraperitoneal injection into immunocompromised mice also treated with or without PIO at multiple time points after peritoneal surgery. The presence and extent of adhesions were examined in animals relative to the initial establishment of experimental endometriosis.

Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes.

Objective: To develop a chimeric human/mouse model of experimental endometriosis for the examination of the role of human immune cells in this disease.

Design: Laboratory-based study.

Setting: University-affiliated medical center.