Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder: A Systematic Review.

Objective:  To analyze the scientific production regarding maternal folic acid (FA) supplementation and its relationship with autistic spectrum disorder (ASD).

Data Sources:  We performed unrestricted electronic searches in the BIREME virtual bank, Virtual Health Library (VHL) and Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed) databases.

Selection Of Studies:  For sample selection, articles that met the proposed objectives were included, published in English, Spanish and Portuguese, the use of Health Sciences Descriptors (DeCS): OR AND AND , AND, with the use of the Medical Subject Headings (MeSH): autistic OR AND AND .