Synopsis of recent research by authors named "Alessandra Agresti"
- Alessandra Agresti's research primarily focuses on the dynamics of nuclear factor κB (NF-κB) signaling in various cellular contexts, exploring its roles in diseases such as multiple myeloma and chronic inflammatory conditions like giant cell arteritis.
- Recent findings highlight the heterogeneous activation of NF-κB in multiple myeloma cells and how small transcriptional variations among cell clones can lead to distinct NF-κB dynamics, affecting immune responses and transcriptional programs.
- Agresti's work also investigates the role of trained immunity in the pathogenesis of inflammatory diseases, the impact of aging and inflammation on germ cell aplasia, and seeks potential biomarkers for COVID-19 outcomes linked to systemic inflammation.
