Publications by authors named "Alesandro Civljak"
SARS-CoV-2 mRNA vaccines induce robust and persistent germinal centre (GC) B cell responses in humans. It remains unclear how the continuous evolution of the virus impacts the breadth of the induced GC B cell response. Using ultrasound-guided fine needle aspiration, we examined draining lymph nodes of nine healthy adults following bivalent booster immunization.
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- The study explores how vaccines specifically designed for the Omicron XBB.1.5 variant can generate effective B-cell responses, focusing on the antibody responses in individuals who received a monovalent vaccine.
- Researchers analyzed immune responses from 603 plasmablasts, expressing 100 human monoclonal antibodies to assess their effectiveness against various SARS-CoV-2 variants.
- Two specific monoclonal antibodies, M2 and M39, were identified; M2 targeted only XBB.1.5 while M39 could neutralize both XBB.1.5 and JN.1, highlighting the functional potential of variant-specific vaccines.