Publications by authors named "Alequis Pavon Oro"

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts primarily due to antiplatelet autoantibodies. Anti-D is a donor-derived polyclonal Ab against the rhesus D Ag on erythrocytes used to treat ITP. Unfortunately, adverse inflammatory/hypersensitivity reactions and a Food and Drug Administration-issued black box warning have limited its clinical use.

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Fc gamma receptor (FcγR) IIIA is an important receptor for immunoglobulin G (IgG) and is involved in immune defense mechanisms as well as tissue destruction in some autoimmune diseases including immune thrombocytopenia (ITP). FcγRIIIA on macrophages can trigger phagocytosis of IgG-sensitized platelets, and prior pilot studies observed blockade of FcγRIIIA increased platelet counts in patients with ITP. Unfortunately, although blockade of FcγRIIIA in patients with ITP increased platelet counts, its engagement by the blocking antibody drove serious adverse inflammatory reactions.

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Article Synopsis
  • The study analyzed the neutralizing antibody responses in human sera from individuals immune to DENV-3, focusing on samples collected from patients during the 2001-2002 Havana dengue epidemic.
  • Twenty serum samples were evaluated for their effectiveness against seven different DENV-3 strains, showing stronger neutralizing activity against genotype III compared to genotype V.
  • Results indicated that antibody levels varied by the timing of sample collection during the epidemic and that the virus may have evolved during this period, raising important questions for future dengue vaccines and understanding disease progression.
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