Publications by authors named "Alena V Tiselko"
Mol Med Rep
December 2019
Article Synopsis
- - The study investigated genetic variants responsible for monogenic diabetes in 60 Russian children diagnosed with non-type 1 diabetes before age 18, utilizing whole-exome sequencing across 35 genes associated with MODY and neonatal diabetes.
- - Researchers identified 38 genetic variants in 55% of patients, with a significant majority linked to MODY-related genes, particularly GCK, while a smaller group had variants in MODY-unrelated genes.
- - The findings suggest a high occurrence of various genetic variants, emphasizing the importance of starting monogenic diabetes diagnostics in Russian children with GCK testing, while also highlighting the effectiveness of whole-exome sequencing for identifying rare variants.
