[IgA Nephropathy. Facts, uncertainties, and potential causal therapy approaches].

IgA nephropathy is currently the most frequently investigated glomerulonephritis. The disease is defined by the presence of dominant or co-dominant deposits of IgA1 in the glomerular mesangium. Circulating immune complexes are most likely the source of the deposited IgA1.

Exposition of dermatophyte Trichophyton mentagrophytes to L-cystine induces expression and activation of cysteine dioxygenase.

Cysteine dioxygenase (CDO) is involved in regulation of intracellular cysteine levels by catabolising the cysteine to sulphite and sulphate. In keratinolytic fungi, sulphite is actively excreted to reduce disulphide bridges in keratin before its enzymatic degradation. The pathogenicity role of CDO was confirmed in cysteine-hypersensitive and growth-defective ΔCdo mutant of Arthroderma benhamiae on hair and nails.

The possible role of dermatophyte cysteine dioxygenase in keratin degradation.

Cysteine dioxygenase (CDO, EC 1.13.11.

Isolation of recombinant cysteine dioxygenase protein from Trichophyton mentagrophytes.

Cysteine dioxygenase (CDO, EC 1.13.11.