Publications by authors named "Alena Hornak"
Background And Purpose: The quality of resting-state functional MRI (rs-fMRI) under anesthesia is variable and there are no guidelines on optimal image acquisition or anesthesia protocol. We aim to identify the factors that may lead to compromised clinical rs-fMRI under anesthesia.
Materials And Methods: In this cross-sectional study, we analyzed clinical rs-fMRI data acquired under anesthesia from 2009-2023 at Massachusetts General Hospital.
Article Synopsis
- * Surgical treatment for tumor-related epilepsy shows better outcomes, with a higher rate of seizure freedom (79%) compared to those with FCD (66%), though this difference isn't statistically significant.
- * The study highlights that pre-operative characteristics and predictive factors for post-surgery outcomes differ between patients with FCD and tumors, suggesting the need for tailored diagnostic approaches in future research.
Article Synopsis
- Functional MRI is crucial for mapping language function before surgery, particularly in children with epilepsy, but sedation for the MRI can influence language activation patterns.
- A study compared language activation in sedated versus awake children with epilepsy, revealing that sedated patients were significantly more likely to exhibit atypical language patterns.
- The findings suggest that sedation during functional MRI can alter how language is mapped in pediatric patients, highlighting the need for careful consideration of sedation protocols in clinical practices.