Publications by authors named "Alena Botalova"
Article Synopsis
- The text discusses the traditional use of yellow toadflax (Linaria vulgaris) in Russian medicine to alleviate hangover symptoms, amidst concerns about alcohol's negative behavioral effects.
- The research involved testing the effects of yellow toadflax extract and its flavonoid, acetylpectolinarin (ACP), on cultured hippocampal neurons exposed to ethanol.
- Findings indicate that ACP can block the increased network activity caused by low ethanol concentration by interacting with SK channels, but it doesn't counteract the suppressive effects of higher ethanol levels.
Ethnopharmacological Relevance: The aqueous extract of the plant Malmpyrum pratense (Mp), is widely used in traditional medicine as a sedative, yet the biological basis of its action is not known.
Aim Of The Study: The effects of Mp on network activity and intrinsic and synaptic properties were studied in cultured hippocampal neurons in an attempt to analyze its mode of action.
Materials And Methods: Dissociated cultures of rat hippocampal neurons were used.
The effects of chronic exposure to moderate concentrations of ethanol were studied in cultured hippocampal neurons. Network activity, assessed by imaging of [Ca(2+)]i variations, was markedly suppressed following 5 days of exposure to 0.25-1% ethanol.
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