Publications by authors named "Alen Joseph"
Introduction: Kratom is commonly used by consumers, and the elemental impurity exposure that consumers would have at different kratom ingestion doses has been determined.
Methods: This assessment used original data from independent third-party laboratory testing of kratom products to identify the percentage of products that exceeded permissible daily exposure limits for lead (5 µg/day), nickel (200 µg/day), arsenic (15 µg/day), and cadmium (5 µg/day), the interim reference level for lead in adults (12.5 µg/day), and the tolerable upper intake level for manganese (11 mg/day) and nickel (1 mg/day).
Article Synopsis
- The study investigated the presence of myositis-specific and myositis-associated autoantibodies (MSAs/MAAs) in a group of Indian children with juvenile dermatomyositis (JDM) and how these antibodies relate to clinical features and patient outcomes.
- A total of 43 children were assessed, with 81.4% testing positive for at least one type of autoantibody; the most common were anti-NXP2, anti-TIF1γ, and anti-MDA-5.
- While many patients showed positive responses to treatment, the study found no clear link between the specific autoantibody profiles and the successful achievement of complete clinical responses or remission.