Introduction: Sheep and goat pox virus (SGPV) is a systemic contagious disease causing extreme illness and death in small ruminants.
Methods: A cross-sectional study was conducted in West Gojjam and Awi zone of Amhara national regional state Northwest Ethiopia, from November 2018 to May 2019 with the objective of pox virus outbreak investigation and molecular detections in sheep and goats (shoats). The study included clinical examinations of lesions, laboratory analysis, and questionnaire survey.