The Last Mile: DSCSA Solution Through Blockchain Technology: Drug Tracking, Tracing, and Verification at the Last Mile of the Pharmaceutical Supply Chain with BRUINchain.

Purpose: As part of the FDA's DSCSA Pilot Project Program, UCLA and its solution partner, LedgerDomain (collectively referred to as the team hereafter), focused on building a complete, working blockchain-based system, BRUINchain, which would meet all the key objectives of the Drug Supply Chain Security Act (DSCSA) for a dispenser operating solely on commercial off-the-shelf (COTS) technology.

Methods: The BRUINchain system requirements include scanning the drug package for a correctly formatted 2D barcode, flagging expired products, verifying the product with the manufacturer, and quarantining suspect and illegitimate products at the last mile: pharmacist to patient, the most complex area of the drug supply chain.The authors demonstrate a successful implementation where product-tracing notifications are sent automatically to key stakeholders, resulting in enhanced timeliness and reduction in paperwork burden.

Super-resolution imaging via spatiotemporal frequency shifting and coherent detection.

Diffraction limit is manifested in the loss of high spatial frequency information that results from decay of evanescent waves. As a result, conventional far-field optics yields no information about an object's subwavelength features. Here we propose a novel approach to recovering evanescent waves in the far field, thereby enabling subwavelength-resolved imaging and spatial spectroscopy.

Negative refraction in semiconductor metamaterials.

An optical metamaterial is a composite in which subwavelength features, rather than the constituent materials, control the macroscopic electromagnetic properties of the material. Recently, properly designed metamaterials have garnered much interest because of their unusual interaction with electromagnetic waves. Whereas nature seems to have limits on the type of materials that exist, newly invented metamaterials are not bound by such constraints.

Semiclassical theory of the hyperlens.

We study ray dynamics inside the hyperlens, a device capable of sub-diffraction-limited far-field imaging. An analytical result for the ray trajectories inside the hyperlens is obtained using Hamiltonian optics, which offers an alternative description of the device. It is also found that the ray trajectories can exhibit a unique spiraling nature inside the device.

[New possibilities of genotypic in the prediction of the likelihood of autoimmune diseases].

The purpose of the study was to estimate the incidence of thyroid dysfunction and cardiovascular diseases in perimenopausal females. The cross-sectional study covered 554 females (mean age 52.6±6.

Slow light and 3D imaging with non-magnetic negative index systems.

We demonstrate that strongly anisotropic planar dielectric systems can be used to create waveguides supporting modes with extremely slow group velocity. Furthermore, we show that such systems can be used for 3D imaging, with a potential for subwavelength resolution.

Optical Hyperlens: Far-field imaging beyond the diffraction limit.

We propose an approach to far-field optical imaging beyond the diffraction limit. The proposed system allows image magnification, is robust with respect to material losses and can be fabricated by adapting existing metamaterial technologies in a cylindrical geometry.