Isolated Hypoglossal Nerve Palsy as an Early Symptom of a Granular Cell Tumor.

Background: Hypoglossal nerve palsy (HNP) is rather common as a neurological disease. However, as an isolated nerve palsy it is an exceedingly rare phenomenon and points at local pathologies along the peripheral course of the nerve. In this communication we report a granular cell tumor (GCT) arising in the submandibular segment of the hypoglossal nerve.

Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern.

In the absence of virus-targeting small-molecule drugs approved for the treatment and prevention of COVID-19, broadening the repertoire of potent SARS-CoV-2-neutralizing antibodies represents an important area of research in response to the ongoing pandemic. Systematic analysis of such antibodies and their combinations can be particularly instrumental for identification of candidates that may prove resistant to the emerging viral escape variants. Here, we isolated a panel of 23 RBD-specific human monoclonal antibodies from the B cells of convalescent patients.

Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest.

The impairments of cerebral blood flow microcirculation brought on by cardiac and respiratory arrest were assessed with multi-modal diagnostic facilities, utilising laser speckle contrast imaging, fluorescence spectroscopy and diffuse reflectance spectroscopy. The results of laser speckle contrast imaging show a notable reduction of cerebral blood flow in small and medium size vessels during a few minutes of respiratory arrest, while the same effect was observed in large sinuses and their branches during the circulatory cessation. Concurrently, the redox ratio assessed with fluorescence spectroscopy indicates progressing hypoxia, NADH accumulation and increase of FAD consumption.

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study.

This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibility studies and actual tests on laboratory mice with inoculated hepatocellular carcinoma and in clinical conditions on patients with liver tumors are presented and discussed.

Coupled-channel study of the Rydberg-valence interaction in HBr.

We report an ab initio study of the low-lying valence and Rydberg states of HBr. The calculations are carried out employing the multireference single- and double-excitation configuration interaction method including the spin-orbit interaction. The first excited adiabatic potential of Σ symmetry presents two minima which correspond to the Rydberg EΣ and valence VΣ observed states.

Calibration of a thin metal foil for infrared imaging video bolometer to estimate the spatial variation of thermal diffusivity using a photo-thermal technique.

A thin metal foil is used as a broad band radiation absorber for the InfraRed imaging Video Bolometer (IRVB), which is a vital diagnostic for studying three-dimensional radiation structures from high temperature plasmas in the Large Helical Device. The two-dimensional (2D) heat diffusion equation of the foil needs to be solved numerically to estimate the radiation falling on the foil through a pinhole geometry. The thermal, physical, and optical properties of the metal foil are among the inputs to the code besides the spatiotemporal variation of temperature, for reliable estimation of the exhaust power from the plasma illuminating the foil.

[Optimised rate of specific, revascularising therapies in acute stroke--what is the aim? Considerations from the experience of a tertiary centre].

Background: Recanalisation favourably influences outcome in acute stroke. Improved endovascular approaches seem to have higher recanalisation rates than systemic thrombolysis. Substantial efforts have been undertaken to increase the proportion of patients to whom these therapies can be applied.

Potential energy surfaces for ground and excited electronic states of the CF3I molecule and their relevance to its A-band photodissociation.

The multireference spin-orbit (SO) configuration interaction (CI) method in its Λ-S contracted SO-CI version is employed to calculate two-dimensional potential energy surfaces for the ground and low-lying excited states of CF3I relevant to its photodissociation in the lowest absorption band (A band). The computed equilibrium geometry for the X̃A1 ground state and vibrational frequency ν3 for the C-I stretch mode agree well with available experimental data. The (3)Q0(+) state dissociating to the excited I((2)P1/2) limit is found to have a minimum of 1570 cm(-1) significantly shifted to larger internuclear distances (RC-I = 5.

The vibrationally mediated photodissociation of Cl2.

The photodissociation of vibrationally excited Cl(2)(v = 1) has been investigated experimentally using the velocity mapped ion imaging technique. The experimental measurements presented here are compared with the results of time-dependent wavepacket calculations performed on a set of ab initio potential energy curves. The high level calculations allow prediction of all the dynamical information regarding the dissociation, including electronic polarization effects.

AsH3 ultraviolet photochemistry: an ab initio view.

Multireference configuration interaction calculations have been carried out for low-lying electronic states of AsH(3). Bending potentials for the nine lowest states of AsH(3) are obtained in C(3v) symmetry for As-H distances fixed at the ground state equilibrium value of 2.850 a(0), as well as for the minimum energy path constrained to R(1) = R(2) = R(3).

Electronic polarization effects in the photodissociation of Cl2.

Velocity mapped ion imaging and resonantly enhanced multiphoton ionization time-of-flight methods have been used to investigate the photodissociation dynamics of the diatomic molecule Cl(2) following excitation to the first UV absorption band. The experimental results presented here are compared with high level time dependent wavepacket calculations performed on a set of ab initio potential energy curves [D. B.

A complete quantum mechanical study of chlorine photodissociation.

A fully quantum mechanical dynamical calculation on the photodissociation of molecular chlorine is presented. The magnitudes and phases of all the relevant photofragment T-matrices have been calculated, making this study the computational equivalent of a "complete experiment," where all the possible parameters defining an experiment have been determined. The results are used to simulate cross-sections and angular momentum polarization information which may be compared with experimental data.

Multimodal CT imaging and recanalizing therapy in acute ischemic stroke: retrospective analysis of a one-year single-center experience.

Background: Recanalizing therapy in ischemic stroke is restricted to thrombolysis within 3 h. Multimodal imaging of vessel and parenchymal perfusion status may allow the extension of this time window.

Aim: To retrospectively analyze treatment results of any recanalizing therapy in clinical practice.

Ab initio calculations of the electronic states of AsH2 including dissociation characteristics.

Multireference configuration interaction calculations have been carried out for low-lying electronic states of AsH(2). Bending potentials for the ten lowest states of AsH(2) are obtained in C(2v) symmetry for As-H distances fixed at the the ground state equilibrium value of 2.845 a(0), as well as for the minimum energy path constrained to R(1) = R(2).

Ab initio configuration interaction study of the B- and C-band photodissociation of methyl iodide.

Multireference spin-orbit configuration interaction calculations have been carried out for the valence and low-lying Rydberg states of CH(3)I. Potential energy surfaces along the C-I dissociation coordinate (minimal energy paths with respect to the umbrella angle) have been obtained as well as transition moments for excitation of the Rydberg states. It is shown that the B and C absorption bands of CH(3)I are dominated by the perpendicular (3)R(1),(1)R (E)←X̃ A(1) transitions, while the (3)R(2)(E), (3)R(0(+) )(A(1))←X̃ A(1) transitions are very weak.

Effect of allofibroblast transplantation on the wound process and its outcomes in burned patients.

Clinical and morphological studies of the effects of allofibroblast transplantation on the wound process were carried out in patients with extensive deep burns. Transplantation of allofibroblast culture stimulated the reparation process, promoted rapid increase in the counts of fibroblasts and functionally active macrophages, formation of normal granulation tissue, and early effective autodermoplasty. Transplantation reduced the number of operations and treatment duration and costs and ensured better esthetic results.

Diagnosis of leptomeningeal disease in diffuse large B-cell lymphomas of the central nervous system by flow cytometry and cytopathology.

Reliable detection of leptomeningeal disease has the potential of facilitating the diagnosis of central nervous system (CNS) lymphoma and is important for therapeutic considerations. Currently, the standard diagnostic procedure for the detection of lymphoma in the cerebrospinal fluid is cytopathology. To improve the limited specificity and sensitivity of cytopathology, flow cytometry has been suggested as an alternative.

Detection of free immunoglobulin light chains in cerebrospinal fluids of patients with central nervous system lymphomas.

Diagnosis of central nervous system (CNS) lymphoma depends on histopathology of brain biopsies, because no reliable disease marker in the cerebrospinal fluid (CSF) has been identified yet. B-cell lymphomas such as CNS lymphomas are clonally restricted and express either kappa or lambda immunoglobulin light chains. The aim of this study was to find out a potential diagnostic value of free immunoglobulin light chains released into the CSF of CNS lymphoma patients.

On the ultraviolet photofragmentation of CH3Xe+.

The multireference spin-orbit configuration interaction method is employed to calculate potential energy surfaces for the ground and low-lying excited states of the CH(3)Xe(+) cation as functions of the Xe-C bond length and the Xe-C-H angle. It is shown that the X (1)A(1) ground state of CH(3)Xe(+) is well bound (D(e)=1.78 eV) and dissociates to the CH(3)(+)(X (1)A(1)(')) + Xe((1)S) limit.

Spin-orbit configuration interaction study of the ultraviolet photofragmentation of XeH+.

The multireference spin-orbit CI method is employed to calculate potential energy curves for the ground and low-lying excited states of the XeH+ cation. For the first time, the spin-orbit interaction is taken into account and electric dipole moments are computed for transitions to the states responsible for the first absorption continuum (A band) of XeH+. On this basis, the partial and total absorption spectra in this energy range are obtained.

Ab initio study of the KrH+ photodissociation.

The multireference spin-orbit configuration interaction method is employed to calculate potential energy curves for the ground and low-lying excited states of the KrH(+) cation. For the first time, the spin-orbit interaction is taken into account and electric dipole moments are computed for transitions to the states responsible for the first absorption continuum (A band) of KrH(+). On this basis, the partial and total absorption spectra in this energy range are obtained.

Theoretical study of the ArH+ photodissociation.

The multireference Spin-Orbit (SO) Configuration Interaction (CI) method in its Lambda-S Contracted SO-CI (LSC-SO-CI) version is employed to calculate potential energy curves for the ground and low-lying excited states of the ArH(+) cation. For the first time, electric dipole moments are also computed in the approach, including SO coupling for transitions to the states responsible for the first absorption continuum (A-band) of ArH(+). On this basis, the partial and total absorption spectra in this energy range are obtained.

An ab initio study of the CH3I photodissociation. II. Transition moments and vibrational state control of the I* quantum yields.

Multireference spin-orbit configuration interaction calculations of transition moments from the X A1 ground state to the 3Q0+, 3Q1, and 1Q excited states responsible for the A absorption band of CH3I are reported and employed for an analysis of the photofragmentation in this system. Contrary to what is usually assumed, the 3Q0+(A1), 3Q1(E), and 1Q(E)<--X A1 transition moments are found to be strongly dependent on the C-I fragmentation coordinate. The sign of this dependence is opposite for the parallel and perpendicular transitions, which opens an opportunity for vibrational state control of the photodissociation product yields.

An ab initio study of the CH3I photodissociation. I. Potential energy surfaces.

The multireference spin-orbit (SO) configuration interaction (CI) method in its Lambda-S contracted SO-CI version is employed to calculate two-dimensional potential energy surfaces for the ground and low-lying excited states of CH3I relevant to the photodissociation process in its A absorption band. The computed equilibrium geometry for the X A1 ground state, as well as vibrational frequencies for the nu2 umbrella and nu3 symmetric stretch modes, are found to be in good agreement with available experimental data. The 3Q0+ state converging to the excited I(2P1/2o) limit is found to possess a shallow minimum of 850 cm(-1) strongly shifted to larger internuclear distances (RC-I approximately 6.