Prospective comparative study of intraoperative balloon electronic brachytherapy versus resection with multidisciplinary adjuvant therapy for recurrent glioblastoma.

Background: Intraoperative balloon electronic brachytherapy (IBEB) may provide potential benefit for local control of recurrent cerebral glioblastomas (GBMs).

Methods: This is a preliminary report of an open-label, prospective, comparative cohort study conducted in two neurosurgical centers with ongoing follow-up. At recurrence, patients at one center ( = 15) underwent reresection with IBEB while, at the second center ( = 15), control subjects underwent re-resection with various accepted second-line adjuvant chemoradiotherapy options.

Stereotactic radiosurgery and hypofractionated stereotactic radiotherapy for management of vestibular schwannomas: initial experience with 17 cases.

Background: Nowadays radiation treatment of patients with vestibular schwannomas (VSs) applied either as stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT) represents a real alternative to surgical tumor resection.

Methods: During 2010-2011, 17 consecutive patients (19-75 years old) with a VS underwent treatment with SRS or SRT in our center. Microsurgery was initially offered in all cases but was declined for various reasons.