Publications by authors named "Aleksei Kondrashov"
Article Synopsis
- * ADCs use different cytotoxic agents, like microtubular inhibitors and topoisomerase inhibitors, and their effectiveness can be influenced by the specific linkers that connect these components, which help activate the drug at the target site.
- * Currently, six ADCs are FDA-approved for various solid tumors, but challenges such as tumor cell adaptation and high costs may limit their effectiveness and accessibility, while ongoing research is exploring new ADCs for improved cancer treatments.
Hereditary cancer predisposition syndromes (HCS) become more recognizable as the knowledge about them expands, and genetic testing becomes more affordable. In this review, we discussed the known HCS that predispose to central and peripheral nervous system tumors. Different genetic phenomena were highlighted, and the important cellular biological alterations were summarized.
View Article and Find Full Text PDFBackground Full-endoscopic spinal surgery is an evolving technique. A laborious learning phase is inevitable due to the complexity of the orientation and instrumentation. The goal of the present study is to evaluate a single surgeon's learning curve and early outcomes in full-endoscopic resection of lumbar disc herniations.
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