Publications by authors named "Aleksandra W Babnis"
Article Synopsis
- Mammalian innate immune pathways utilize nucleotide-based second messengers like 2'3'-cGAMP and 2'-5' oligoadenylates (OAs) to activate key proteins STING and RNase L, indicating an evolutionarily conserved mechanism to trigger antiviral responses.
- A study using mass spectrometry found several members of the ABCF protein family in various species, highlighting their role as 2'-5' OA-binding proteins, with ABCF1 showing high-affinity binding to phosphorylated 2'-5' OA.
- Despite these interactions, the research did not find strong antiviral functions in the ABCF proteins or Decr1, suggesting that 2'-5' OAs may act primarily as signaling hubs, necess
Viruses pose substantial challenges for society, economy, healthcare systems, and research. Their distinctive pathologies are based on specific interactions with cellular factors. In order to develop new antiviral treatments, it is of central importance to understand how viruses interact with their host and how infected cells react to the virus on a molecular level.
View Article and Find Full Text PDFTransporter associated with antigen processing (TAP), a key player in the major histocompatibility complex class I-restricted antigen presentation, makes an attractive target for viruses that aim to escape the immune system. Mechanisms of TAP inhibition vary among virus species. Bovine herpesvirus 1 (BoHV-1) is unique in its ability to target TAP for proteasomal degradation following conformational arrest by the UL49.
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